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You will have to be extra diligent when preparing your area for a groundcover if the site contains perennial weeds such as creeping charlie, thistle or bindweed. They are persistent and difficult to control even in established groundcovers because of regeneration from their root fragments. You may try treating them with a nonselective broadleaf herbicide applied with a brush, cloth or wick applicator, but CARE is advised since these herbicides will kill the ground cover if it is applied to their foliage.